Beilstein J. Org. Chem.2020,16, 818–832, doi:10.3762/bjoc.16.75
Analytical Chemistry, University of Debrecen, H-4032 Debrecen, Hungary 10.3762/bjoc.16.75 Abstract A series of 1-substituted-3-methyl-2-phospholeneoxides was prepared from the corresponding 3-phospholene oxides by double bond rearrangement. The 2-phospholeneoxides could be obtained by heating the 3
double bond migration pathways were elucidated by quantum chemical calculations.
Keywords: chlorophosphonium salts; isomerization; 2-phospholeneoxides; 3-phospholene oxides; quantum chemistry; Introduction
P-Heterocyclic derivatives are valuable targets in synthetic organophosphorus chemistry [1][2][3
strategies for 2-phospholeneoxides (Figure 1).
A convenient strategy may involve the isomerization of 3-phospholene oxides to the corresponding 2-phospholeneoxides. A few isomerizations resulting 2-phospholene derivatives have already been observed and published in the literature [58][59][60][61]. However
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Graphical Abstract
Figure 1:
Examples for catalytically or biologically active molecules containing five-membered P-heterocyclic...